APJ AS PROMISING THERAPEUTIC TARGET OF PEPTIDE ANALOGUES IN MYOCARDIAL INFARCTION- AND HYPERTENSION-INDUCED HEART FAILURE

APJ as Promising Therapeutic Target of Peptide Analogues in Myocardial Infarction- and Hypertension-Induced Heart Failure

The widely expressed G protein-coupled apelin receptor (APJ) is activated by two bioactive endogenous peptides, apelin and ELABELA (ELA).The apelin/ELA-APJ-related pathway has been found involved in the regulation of many physiological and pathological cardiovascular processes.Increasing studies are deepening the role of the APJ pathway in limiting

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Novel Components of the Flagellar System in Epsilonproteobacteria

ABSTRACT Motility is essential for the pathogenesis of many bacterial species.Most bacteria move using flagella, which are multiprotein filaments that rotate propelled by a cell wall-anchored motor using chemical energy.Although some components of the flagellar apparatus are common to many bacterial species, recent studies have shown significant di

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